Biomedical Product Design Final Report

Table of Contents

1.0 Overview

1.1 Need 1.2 Specifications

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1 2

2.0 Overview

2.1 Analysis to Chose Design Concept 2.2 Overview of Design

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3.0 Analysis and Calculations 4.0 Design Details

4.1 Granite Base 4.2 Sample Holder 4.3 Probe Mount 4.4 Tissue Slicer 4.5 Software 4.6 Wiring 4.7 Safety

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5.0 Manufacturing and Materials

5.1 Granite Base 5.2 Sample Holder 5.3 Probe Mount 5.4 Tissue Slicer 5.5 Electronics 5.6 Total Price

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36 37 40 45 46 48

6.0 Conclusions 7.0 References A1. Design Specifications A2. Product Specifications A3. Company Contact Information

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1.0 Overview

1.1 Need

There is currently a high demand for an imaging device that can produce high-resolution threedimensional images that contain information about the structure of excised tissue. This device would need to be able to image an entire section of a human organ to be truly useful. There are imaging modalities such as Optical Coherence Tomography (OCT) that can create such types of images; however, the depth of penetration those imaging modalities allow is in the range of 12mm. Thus, cardiology research laboratories, and other laboratories that investigate tissue samples on larger scale would benefit from a device that could produce three-dimensional images of whole biological compartments, for example of the Sino-atrial node (SAN) of heart the main pacemaker of the heart, the Atrio-ventricular node (AVN) - the second pacemaker of the heart, the ventricular heart wall, or other biological compartments. For example, a highresolution 3D image of the ventricular heart wall, with thickness of approximately 10-30mm, will show the muscle fiber orientation.

A researcher could pick two areas of interest, a couple of millimeters apart, of a ventricular heart wall piece, image both areas with a 3D imaging device and analyze to compare the difference in fiber orientation. It will be more beneficial to observe and analyze...