Seven Deaths

1. Are there any similarities or connections between these seven individuals? Same neighborhood, and same symptoms. What questions would you want to ask the families to answer these questions? How did they go missing and what things did they do before they were kidnapped.

2. In your opinion, are these seven deaths connected? Yes, because all of them live in the same neighborhood and had the same symptoms. And all of them took the same pills.

1. Recalling your knowledge of the function of organelles, what function of the cells was interrupted in these patients? Mitochondrial. Could this loss of function lead to the death of these individuals? Yes, because there oxygen level in the blood was too high. (It was a 110 mm Hg)

2. Given the data in the autopsy, were there any reports that seemed inconsistent with the immediate cause of death? Immediate cause of death was hypoxia (suffocation or lack of oxygen). Tissue sections from heart, lung, kidney, and liver all show massive cell death.

1. For each metabolite listed in the table, describe its role in cellular respiration? Glucose is the starting molecule, and i split during glycolysis and forms 2 pyruvate molecules. In glycolysis 2 molecules of ATP are used up and 4 are produced (so a net production of 2 ATP molecules). Glucose + 2 NAD+ + 2 Pi + 2 ADP → 2 pyruvate + 2 NADH + 2 ATP + 2 H+ + 2 H2O + heat. Are they substrates or products? Substrates. What is their main function? Cell respiration

2. Are there any abnormalities in the levels of these metabolites in the victims? Yes, the NAD+ and NADH. Develop a hypothesis about which pathway may be affected based on these abnormalities. NAD+ is 10mm for the patients and the normal levels are 75mm. And NADH is 400mm for the patients and the normal levels is 50 mm.

3. Explain your reasoning for your hypothesis. The NAD+ and NADH are the only metabolites that went below and high. Which means something in the pill has affected those two metabolites.

1. What affect...