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Interleukin 2

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Interleukin 2 |

Human Interleukin 2 crystal structure |

[show]Available structures |

PDB | 1irl, 1m47, 1m48, 1m49, 1m4a, 1m4b, 1m4c, 1nbp, 1pw6, 1py2, 1qvn, 1z92, 2b5i, 2erj, 3ink |

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Identifiers |

Symbols | IL2; IL-2; TCGF; lymphokine |

External IDs | OMIM: 147680 MGI: 96548 HomoloGene: 488 GeneCards: IL2 Gene |

[show]Gene Ontology |

Molecular function | • cytokine activity

• interleukin-2 receptor binding

• kinase activator activity |

Cellular component | • extracellular region

• extracellular space |

Biological process | • anti-apoptosis

• immune response

• cell adhesion

• cell-cell signaling

• positive regulation of cell proliferation

• antimicrobial humoral response

• natural killer cell activation

• T cell differentiation

• positive regulation of cell growth |

Sources: Amigo / QuickGO |

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RNA expression pattern |

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More reference expression data |

Orthologs |

Species | Human | Mouse | |

Entrez | 3558 | 16183 | |

Ensembl | ENSG00000109471 | n/a | |

UniProt | P60568 | n/a | |

RefSeq (mRNA) | NM_000586 | NM_008366 | |

RefSeq (protein) | NP_000577 | NP_032392 | |

Location (UCSC) | Chr 4:

123.59 - 123.6 Mb | n/a | |

PubMed search | [1] | [2] | |

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity.

Contents[hide] * 1 Discovery and characterization * 2 IL-2 signaling pathway * 3 Physiology and immunology * 4 Immunotherarpy * 5 References * 6 External links |

Discovery and characterization

IL-2 was the first interleukin molecule to be discovered[citation needed]. The discovery of the first...