Higher Spending on Coagulation Disorders to Push Global Heparin Market to Us$14.3 Bn by 2023

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Date Submitted: 02/24/2016 03:52 AM

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Anticoagulants as a medicine either work by altering or inhibiting steps in the coagulation cascade. Heparin is administered intravenously or subcutaneously which functions by inhibiting the effects of antithrombin and Factor Xa. Patients suffering from stroke and unstable angina are usually recommended heparin therapy owing to rapid onset of anticoagulation activity. Additionally, heparin is also advised to patients suffering from stroke or transient ischemic attack. Heparin is also among the most widely used anticoagulant after warfarin during surgical procures and treatment of coagulation disorders such as deep vein thrombosis (DVT) and pulmonary embolism (PE).

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The report on global heparin market by products has been studied for unfractionated heparin, low molecular weight heparin (LMWH) and ultra-low molecular weight heparin (ULMWH). Unfractionated heparin is one of the most primitive forms of heparin commonly used during dialysis and in heart lung machines as a measure to prevent blood clots. Unfractionated heparin has variable anticoagulant effect with limited bioavailability which is a major drawback affecting sales and acceptance with heparin base products. However, heparin overdose associated with unfractionated heparin can be easily reversed with protamine sulfate as compared to LMWHs and ULMWHs. Due to its large molecular size and anionic structure, unfractionated heparin is not absorbed reliably in the gastrointestinal tract when administrated orally. Heparin induced thrombocytopenia and hemorrhage are some of the major adverse effects of unfractionated heparin therapy.

LMWH products have smaller and more uniform molecular weights than unfractionated heparin leading to greater affinity for Factor Xa than Factor IIa. Compared to unfractionated heparin, LMWHs have enhanced safety and efficacy. LMWHs accounted for the largest market share in 2014 owing to...