Submitted by: Submitted by mariakristina
Views: 644
Words: 391
Pages: 2
Category: Science and Technology
Date Submitted: 02/28/2011 07:14 AM
ABSTRACT
One of the leading causes of Filipino’s mortality is Diabetes Mellitus and its related complication. In order to compensate with the high cost of its treatment and maintenance medication, it is indeed a challenge to produce a more cost effective medicine that would be financially and therapeutically beneficial. Hibiscus rosa-sinensis, which is locally known as gumamela, is abundant in the country as an ornamental plant. Is also use traditionally as an expectorant, diuretic, emollient, anti-inflammatory, antiseptic, antipyretic, anodyne and refrigerant drink. International studies claimed of its hypoglycemic activity. To further scrutinize its constituents and potential as a hypoglycemic agent, experimental methods have been conducted. The plant samples have been collected and have been extracted and immediately undergone a series of physical, organoleptic and phytochemical testing. Before finally forerunning to a biological test, the extract’s toxicity has been tested in a small population of mice by administering a varying concentration via intraperitoneal route which turns out to be agreeable. Mus musculus albinus is the test animal used. The total population is 18, all were female weighing an average of 20-25 grams, 4-6 weeks old. After a week of animal acclimatization, alloxan was given to induce diabetes with a dose of 150mg/1000mg. Prior to alloxan administration, the fasting blood glucose-which serves to be the baseline, has been monitored. The population is divided in to 3 control groups, namely: the positive, negative and extract. In the succeeding 3 days, after observing that the blood glucose has reached its diabetic state, the controls are administered. Metformin has been used as the positive control which elicited a high glucose lowering effect on the test animals. However, upon the administration of Normal Saline Solution in the negative control group, consistent increase in the blood glucose level is apparent. Moreover, an acceptable...