Lecture Notes

Lecture

Notes

Chemistry 337

Unit 1 Isolation of trimyristin from nutmeg

Introduction to Unit 1

The centerpiece of Unit 1 is the isolation and characterization of trimyristin. The trimyristin will be isolated from its source

material, ground nutmeg, by solid-liquid extraction. The isolated material will be characterized by melting point determination.

O

CH2O

C

(CH2)12CH3

O

CHO

C

(CH2)12CH3

O

CH2O

C

(CH2)12CH3

Trimyristin

Purpose of Unit 1

To become familiar with the theoretical and practical aspects of solid-liquid extraction as an isolation/purification technique

To become familiar with the theoretical and practical aspects of melting point determination

To quantify the isolated trimyristin as a percent of ground nutmeg

To characterize the isolated trimyristin by melting point determination

Topics of these lecture notes

These lecture notes examine heating and cooling methods, refluxing a reaction mixture, solid-liquid extraction, melting points

and melting ranges and yields (theoretical yield, experimental yield, percent yield)

Lecture notes

I.

Heating and cooling methods

Mohrig, third edition Mohrig, fourth edition

Mohrig essay “Learning to do organic chemistry “

p29-30

p41-43

General comments

Chapter 6 intro

Chapter 6 intro

Preventing bumping of liquids

Section 6.1

Section 6.1

Heating devices (intro, heating mantles and hot plates sections only)

Section 6.2

Section 6.2

Cooling methods (all but the Dewar flasks section)

Section 6.3

Section 6.4

Some important questions/statements

1.

What types of organic reactions require heating?

Those that are very slow at room temperature

2.

What types of organic reactions require cooling?

Those that are exothermic at room temperature

3.

In what manner do liquids boil when heated in

laboratory glassware?

They tend to bump

4.

How many boiling stones should be used to effect

smooth boiling?...