Education Study Guide Test 3

Study Guide 76-80 and 83-87

Chapter 76

1. The mediators involved in the inflammatory process of asthma are histamine_, __leukotrienes_, and _prostaglandins, interleukins_.

2. The two major pharmacologic classes of drugs used to treat asthma are _anti-inflammatory_ and bronchodilators_.

3. Today, all MDIs use __hydrofluoroalkane(HFA) as the propellant.

4. Glucocorticoids reduce asthma symptoms by _suppressing inflammation.

5. The three leukotriene modifiers available are _zileuton, zafirlukast, and Montelukast.

6. Omalizumab (Xolair) is a monoclonal antibody with what unique mechanism of action? _antagonism of IgE_

7. Beta2 agonists benefit patients with asthma by promoting _bronchodilation_.

8. Virtually all patients with asthma use which form of beta2 agonist? _Short-Acting_

9. _Theophylline_ is the primary methylxanthine used in asthma.

10. The four classes of chronic asthma are _Intermittent_, Mild Persistent, Moderate Persistent_, and _Severe Persistent_.

Chapter 77

1. The principal drugs used to treat allergic rhinitis include _Glucocorticoids Antihistamines_(Oral and Intranasal) , and _Sympathomimetics (Oral and (Intranasal).

2. Antihistamines relieve sneezing, rhinorrhea, and nasal itching but they do not reduce nasal congestion.

3. For therapy of allergic rhinitis, antihistamines are most effective when taken prophylactically.

4. What is the only antihistamine available for intranasal use? azelastine.

5. With children, the greatest concern about systemic absorption of intranasal steroids is _slowing of linear growth.

6. How does cromolyn work?

_Reduces symptoms by suppressing the release of histamine and other inflammatory mediators from mast cells.

7. Decongestants are not recommended for patients with _hypertension or _coronary artery disease

8. What drug is a monoclonal antibody directed against immunoglobulin E (IgE)? _Omalizumab

9. The two most frequently used drugs for cough suppression are _codeine and hydrocodone.

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