Exocrine Pancreatic Insufficiency Market to Reach Us$2.85 Bn by 2023

Exocrine pancreatic insufficiency (EPI) is a condition characterized by the deficiency of the exocrine pancreatic enzymes, causing failure to digest food properly. Exocrine pancreatic insufficiency is caused due to damage to pancreas. The common causes of EPI are cystic fibrosis, chronic pancreatitis, and Shwachman-Diamond syndrome. The peculiar symptoms of EPI include frequent diarrhea, weight loss, foul-smelling greasy stools, gas and bloating, and stomach ache. Exocrine pancreatic insufficiency is treatable with pancreatic enzyme replacement therapy, which helps in digestion, improves malabsorption and vitamin deficiencies, and fuels weight gain.

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Pancreatic enzyme replacement therapy products contain a defined amount of digestive enzymes such as lipases, proteases, and amylases, which are required by the body to metabolize fats, proteins, and sugar from food. Without these enzymes, patients with EPI are less capable of absorbing vital nutrients from food and can become undernourished. Effective management of EPI includes life-long pancreatic enzyme replacement therapy (PERT), lifestyle modifications, modifications with specialized food supplements such as vitamins and nutrients that do not require pancreatic enzymes for digestion, and transplantation of pancreatic cells.

Factors such as the increasing prevalence of diseases such as cystic fibrosis, chronic pancreatitis and diabetes are contributing to an increase in the prevalence of exocrine pancreatic insufficiency. According to recent data released by the Cystic Fibrosis Foundation, about 30,000 people are living with cystic fibrosis in the U.S. and 70,000 across the globe. Approximately 1,000 new cases of cystic fibrosis are diagnosed each year in the U.S. With such alarming rise in the number of people suffering from cystic fibrosis, the risk of incidence related to the disease also...