A4M Review

4Leptin (high serum leptin

correlated with increased fat

stores/weight gain; also seen in

IR bec brain not responding to

leptin signals so keep eating>wt gain)

1a

hormone that suppresses appetite,

produced in fat cells, epithelium and

stomach, acts on receptors in

hypothalamus to tell it "I'm full,

stop eating", also stimulates gnRH,

LH, FSH from ant. pituitary

1b

Glucagon

2a

lipolytic, activates triglyceride

lipase in adipose tissue via

cAMP, causes increased blood

levels of fatty acids & glycerol

2b

BMR

3a

amount of daily energy

expended while at rest, only

enough energy is produced for

vital organ functioning, as it

increases, the # of mitochondria

in the body increases as well

3b

Resveratrol

4a

binds to and stimulates Sir2 sirtuin

enzyme mimicking the effect of caloric

restriction on longevity; it modulates

insulin-mediated glucose uptake in

muscles, it inhibits gene expression

profiles associated with skeletal and

cardiac mm aging

4b

CRP

5a

what inflammatory marker is

inversely correlated to bone

mineral density

5b

True

6a

T or F: in both men and

women, GH reduces cortical

osteocalcin; thus it increases

trabecular and cortical bone

content

6b

DHEA

7a

This hormone affects immune function by

increasing monocytes, increasing IGF1, incr B

cells, incr T cell mitogenic response, incr cells

expression of IL2 & IL3, thus fuctionally activating

T lymphocytes; most abundant hormone in the

body; inhibits breast cancer progression, prevents

blood clots, decreases bone loss, increases

memory, increases lean body mass; produced by

cholesterol

7b

Cortisol

8a

only hormone that increases

with age, involved in stress

response, increases BP,

BGlucose, suppresses immune

function

8b

somatostatin

9a

inhibits release of GH and

TSH, decreases gastric

emptying, inhibits GI

hormones

9b

IGF1

10a

active mediator of FH

10b...