Submitted by: Submitted by kwebster33
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Category: Science and Technology
Date Submitted: 12/09/2013 03:50 PM
Cystic Fibrosis OutLine By Tiffany Furleigh
* Cystic Fibrosis
Autosomal Recessive Inheritance
* By Tiffany Furleigh
* Symptoms
* Digestive
* Diarrhea
* Malnutrition
* Reproductive
* Infertility
* Pregnancy Complications
* Respiratory
* Chronic Coughing
* Bacterial Lung Infections
* Scarring of Lungs
* Severe Breathing Problems
* 1 in 3,500 Caucasians
* 1 in 17,000 African Americans
* 1 in 31,000 Asian Americans
* 10 million Americans are carriers of mutated CF gene
* Most common among the Caucasian population
* Diagnosed usually by 2 years of age
Treatment
* Antibiotics to prevent infections
* Chest Percussion Therapy
* Oxygen Therapy
* High protein diet
* Vitamin supplements
Prognosis
* Fatal Childhood Disease left untreated
* Average Life Span is 37 years
* Death by lung problems most common
* Cystic Fibrosis Punnett Square
* Pedigree Chart
* CFTR Gene Mutation
* CFTR gene instructs the transport of chloride ions needed in cells for mucus distribution around cells and organs.
* This regulates the flow of water in and out of cells for homeostasis and mucus placement.
* Lack of proper balance limits the cells mucus production. Too little chloride ions creates thick mucus build up.
* This mutation creates an imbalance in the cell’s membrane mucus that becomes thick and sticky which inhibits the normal function and clogs airways and ducts.
* References
* http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001167/#adam_000107.disease.causes
* http://www.nhlbi.nih.gov/health/health-topics/topics/cf/signs.html
* http://ghr.nlm.nih.gov/condition/cystic-fibrosis
* http://www.nlm.nih.gov/medlineplus/ency/article/000107.htm
*...