Salubrious Effects in Humans of Resveratrol Powder

Resveratrol was reported to be effective against neuronal cell dysfunction and cell death, and, in theory, could be effective against diseases such as Huntington's disease and Alzheimer's disease. Again, this has not yet been tested in humans for any disease.

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There is limited evidence of health effects in humans.

Health effects

Heart disease:

There is little evidence of benefit from resveratrol in those who already have heart disease.

Cancer:

As of 2007, there is no evidence of an effect on cancer in humans.

Metabolism:

There is very little human evidence of an effect of resveratrol on metabolism.There is some promising evidence in rodents.

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Lifespan

The effect of resveratrol on lifespan in humans is unclear as of 2011. There is some evidence of benefit in yeast and mice.However, no benefit has been shown for healthy non-obesemammals.

The mechanisms of resveratrol's apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. Some studies indicates resveratrol activates Sirtuin 1 and PGC-1α and improves the functioning of the mitochondria. Resveratrol's ability to directly activate sirtuin 1 has been called into question, however newer research has reconfirmed this link.

In cells treated with resveratrol, a fourteen-fold increase in the action of MnSOD (SOD2) is observed.MnSOD reduces superoxide to hydrogen peroxide (H2O2), but H2O2 is not increased due to other cellular activity. Superoxide O2? is a byproduct of respiration in complexes 1 and 3 of the electron transport chain. It is "not highly toxic, but can extract an electron from biological membrane and other cell components, causing free radical chain reactions. Therefore it is essential for the cell to keep superoxide anions in check."

MnSOD reduces superoxide and...