Bio 513 Final Exam Solutions

BIO 513 Final Exam Solutions

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BIO 513 Final Exam Solutions

Question 1:

We started this class with each student providing a definition of a virus. Nearly 800 pages of text

reading and over 900 discussion board posts later, how has your personal definition of a virus

evolved? Write a paragraph (150 words or less) providing a comprehensive definition of a virus.

Comment on how your definition has changed from the beginning of the semester.

Question 2:

Influenza A (H7N9) is one of a subgroup of influenza viruses that normally circulate among

birds. In late March of this year, a number of individuals in and around Shanghai, China were

stricken with severe influenza-like symptoms. These individuals were found to be infected with a

new H7N9 Influenza A virus, which had never before been observed to infect humans. To date,

a total of 108 laboratory-confirmed cases of human infection with avian influenza A (H7N9)

virus, including 22 deaths have been reported to WHO. Answer the following questions about

this virus. (Note: I am not expecting you to research the answer to these questions, but rather

use what you have learned this semester to provide plausible responses)

a) Explain in laymens term what the term H7N9 influenza virus means (3-4 sentences

max).

b) The complete genome sequences of H7N9 virus from three patients have been

determined. The HA gene is most closely related to a 2011 duck H7N3 virus found in

Zhejiang China. The NA gene appears to be almost identical to a H7N9 virus found in

wild birds in Korea. The remaining genes appear to be closely related to a brambling

H9N2 virus found in 2012 near Beijing. Briefly describe likely mechanism(s) of how this

virus might have evolved.

c) Will the current seasonal vaccine influenza A vaccine likely be effective against the

H7N9 virus? How about antivirals such oseltamavir or zanamavir? Why or why not.

d) It is...