Review Article Practical Use of Povidone-Iodine Antiseptic in the Maintenance of Oral Health and in the Prevention and Treatment of Common Oropharyngeal Infections

REVIEW ARTICLE

Practical use of povidone-iodine antiseptic in the

maintenance of oral health and in the prevention and

treatment of common oropharyngeal infections

J. Kanagalingam,1 R. Feliciano,2 J. H. Hah,3 H. Labib,4 T. A. Le,5 J.-C. Lin6

1

SUMMARY

Review criteria

Aims: To better inform medical practitioners on the role of antiseptics in oropharyngeal health and disease, this article focuses on povidone-iodine (PVP-I), an

established and widely-available antiseptic agent. Methodology: Review of the

anti-infective profile, efficacy and safety of PVP-I in managing common upper respiratory tract infections such as the common cold, influenza and tonsillo-pharyngitis, as well as oral complications resulting from cancer treatment (oral mucositis),

and dental conditions (periodontitis, caries). Results: Antiseptics with broad-spectrum anti-infective activity and low resistance potential offer an attractive option

in both infection control and prevention. While there is some evidence of benefit

of antiseptics in a variety of clinical settings that include dental and oral hygiene,

dermatology, oncology, and pulmonology, there appears to be discordance

between the evidence-base and practice. This is especially apparent in the management and prevention of oropharyngeal infections, for which the use of antiseptics varies considerably between clinical practices, and is in marked contrast to

their dermal application, where they are extensively used as both a prophylaxis

and a treatment of skin and wound infections, thus minimising the use of antibiotics. Conclusion: The link between oral and oropharyngeal health status and

susceptibility to infection has long been recognised. The high rates of antibiotic

misuse and subsequent development of bacterial resistance (e.g. increasing vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus

(MRSA)) in large parts of the world, especially across Asia Pacific, highlight the

need...