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Date Submitted: 02/23/2011 06:53 AM
Interleukin 2
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Interleukin 2 |
Human Interleukin 2 crystal structure |
[show]Available structures |
PDB | 1irl, 1m47, 1m48, 1m49, 1m4a, 1m4b, 1m4c, 1nbp, 1pw6, 1py2, 1qvn, 1z92, 2b5i, 2erj, 3ink |
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Identifiers |
Symbols | IL2; IL-2; TCGF; lymphokine |
External IDs | OMIM: 147680 MGI: 96548 HomoloGene: 488 GeneCards: IL2 Gene |
[show]Gene Ontology |
Molecular function | • cytokine activity
• interleukin-2 receptor binding
• kinase activator activity |
Cellular component | • extracellular region
• extracellular space |
Biological process | • anti-apoptosis
• immune response
• cell adhesion
• cell-cell signaling
• positive regulation of cell proliferation
• antimicrobial humoral response
• natural killer cell activation
• T cell differentiation
• positive regulation of cell growth |
Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species | Human | Mouse | |
Entrez | 3558 | 16183 | |
Ensembl | ENSG00000109471 | n/a | |
UniProt | P60568 | n/a | |
RefSeq (mRNA) | NM_000586 | NM_008366 | |
RefSeq (protein) | NP_000577 | NP_032392 | |
Location (UCSC) | Chr 4:
123.59 - 123.6 Mb | n/a | |
PubMed search | [1] | [2] | |
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity.
Contents[hide] * 1 Discovery and characterization * 2 IL-2 signaling pathway * 3 Physiology and immunology * 4 Immunotherarpy * 5 References * 6 External links |
Discovery and characterization
IL-2 was the first interleukin molecule to be discovered[citation needed]. The discovery of the first...