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Lecture
Notes
Chemistry 337
Unit 1 Isolation of trimyristin from nutmeg
Introduction to Unit 1
The centerpiece of Unit 1 is the isolation and characterization of trimyristin. The trimyristin will be isolated from its source
material, ground nutmeg, by solid-liquid extraction. The isolated material will be characterized by melting point determination.
O
CH2O
C
(CH2)12CH3
O
CHO
C
(CH2)12CH3
O
CH2O
C
(CH2)12CH3
Trimyristin
Purpose of Unit 1
To become familiar with the theoretical and practical aspects of solid-liquid extraction as an isolation/purification technique
To become familiar with the theoretical and practical aspects of melting point determination
To quantify the isolated trimyristin as a percent of ground nutmeg
To characterize the isolated trimyristin by melting point determination
Topics of these lecture notes
These lecture notes examine heating and cooling methods, refluxing a reaction mixture, solid-liquid extraction, melting points
and melting ranges and yields (theoretical yield, experimental yield, percent yield)
Lecture notes
I.
Heating and cooling methods
Mohrig, third edition Mohrig, fourth edition
Mohrig essay “Learning to do organic chemistry “
p29-30
p41-43
General comments
Chapter 6 intro
Chapter 6 intro
Preventing bumping of liquids
Section 6.1
Section 6.1
Heating devices (intro, heating mantles and hot plates sections only)
Section 6.2
Section 6.2
Cooling methods (all but the Dewar flasks section)
Section 6.3
Section 6.4
Some important questions/statements
1.
What types of organic reactions require heating?
Those that are very slow at room temperature
2.
What types of organic reactions require cooling?
Those that are exothermic at room temperature
3.
In what manner do liquids boil when heated in
laboratory glassware?
They tend to bump
4.
How many boiling stones should be used to effect
smooth boiling?...