Submitted by: Submitted by spectator101
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Words: 1608
Pages: 7
Category: Science and Technology
Date Submitted: 07/26/2011 08:55 PM
The best way to predict the future is to create it. -Peter Drucker
An Artist’s view of the cell” David Goodshells
Why Proteins vs. the Other Molecules?
• Useful clinically
• Molecular Machinery
Amazing Proteins: Function
• Catalysts (Enzymes)
• Transport and Storage
• Structural
• Generate Movement
• Regulation of Metabolism and Gene Expression
• Protection
• Signaling and Response (inter and intrcellular)
Properties
• Biopolymers of amino acids
• Contains a wide range of functional groups
• Can interact with other proteins or other biological macromolecules to form complex assemblies
• Some are rigid while others display limited flexibility.
Amino Acids: Protein Building Blocks
Synthesis of Proteins
• Different creatures=different Sequences
• N- terminal and C-terminal end
• Zwittertonic
Stereochemistry of Amino Acids
• Wrong handedness= body cannot metabolize
o Thalidomide (switches the handedness)
▪ Do not take if pregnant
o Ex. D-Glucose
Types of Amino Acids
• Aliphatic Side chains
• Cyclic
• OH Side Chains
• Sulfur-containing
o Cysteine-molecular staples, makes glutathione work
o Glutathione is an antioxidant. Helps prevent oxidative phosphorylation
▪ Naturally-made by the body.
▪ Excess: whitening-effect
• Acidic and Acid Derivatives
• Basic Side Chains
Isoelectric Point
• (+)=(-)
• Useful analytically
• For protein analysis, purification, isolation, crystallization
• Lower pH= more (+)
• Higher pH= more (-)
• Acid-base level is important because the shape of the proteins change.
o Different shape=cannot do what they are supposed to do
▪ Get Sick or Die
← Before people wash their...