Chalcones

Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

Chalcone

Chemical name:-

(E)-1,3-diphenyl-prop-2-en-1-one

(2E)-1,3-diphenyl-2-propen-1-one

(E)-1,3-diphenylprop-2-en-1-one

PROPERTIES

Boiling Point:- 345-348 ºC

Melting Point:- 54-57 ºC

Density:- 1.071g/cu.cm

Molar Mass:- 208.26 g mol−1

Exact Mass:- 208.088815

Molecular Formula:- C15H12O

Survival of the fittest is the basis for life and for the human beings also. The biggest threats for human beings are the various diseases and scientists and doctors are still fighting to find solutions with various forms of medications. Today’s developed medicines are results of relentless effort made by human civilization time to time. When the era of synthetic drugs began, it opened thousand doors for the development of various synthetic molecules with potential action.

Chalcones are well known intermediates for synthesizing various heterocyclic compounds. The compounds with the backbone of chalcones (2-PROPENE-1-ONE) have been reported to possess various biological activities such as antimicrobial, anti-inflammatory, antimalarial, antileishmanial, antioxidant, antitubercular, The presence of a reactive α,β-unsatutated keto function in chalcones was found to be responsible for their antimicrobial activity. In the present work we report the reaction of various substituted acetophenone with different substituted aromatic aldehyde to form chalcones. The structures of the various synthesized compounds were assigned on the basis of IR, UV spectral data. These compounds were screened for their antimicrobial activity.

Due to the rapid development of bacterial resistance to antibacterial agents, it is vital to discover novel scaffold for the design and synthesis of the new antibacterial agents to help in the...