Marzano 9-3

A Case of IPT

Directions: Go to attached pdf in the Marzano folder.

Read the case study and answer the following questions.

1. How and where are platelets produced in the body? Platelets are formed in the bone marrow and start off as very large cells. Over time fragments of cytoplasm break off of the larger cell, these fragments are platelets.

2. Describe the role played by platelets in hemostasis. In hemostasis, platelets are responsible for maintaining the endothelial surface. They are one of the first responders to a break in a vessel. They clump together froming clots that stop blood from leaving and bacteria from entering.

3. Define thrombocytopenia and list the more common causes of this condition. Thrombocytopenia is a shortage of platelets in a person’s blood. Causes include Vitamin B deficiency, leukemia, viral or bacterial infection, liver failure and hereditary factors.

4. What are the potential consequences of a low platelet count? Consequences include; increased bruising, larger, deeper bruises, internal bleeding, purpura and fatigue.

5. What drugs have been associated with the development of thrombocytopenia? Valproic acid, methotrexate, carboplatin, interferon, isotretinoin and other chemotherapeutic drugs

6. How is thrombocytopenia treated in individuals diagnosed with the condition? It is usually treated by addressing the underlying cause of thrombocytopenia. If it is caused by a drug, the use of the drug will be discontinued in the patient. Drugs may be used to stimulate bone marrow to increase platelet production. Platelet transfusions may also be necessary.

7. How might removal of the spleen (splenectomy) result in an increase in the number of circulating platelets? The spleen is responsible for removing old platelets from the blood; if it is removed the platelet count in the blood may rise to extremely high levels which could lead to a life threatening clot.

8. What is Idiopathic...