Application of Ngs Technique for Human Health and Medicine

Modern developments in Deoxyribonucleic acid (DNA) sequencing technology allow comprehension of the genetic variations that exist in assorted population samples. As a result, developments are being made to provide an economically sustainable means of doing research on human genetics. Some of the core projects related to Next generation sequencing include the famous 1000 Genomes project, exome sequencing schemes and the cancer genome atlas1 (p.8). The intention of these projects is to explicate genetic spectrum in the context of human character. This would further help in unveiling architectural morphology of human diseases through examination of the structure of the human genome. The capability to investigate the intact genome with impartiality would enable medical researchers understand variations in ordinary infections as well as the nature of mutants 2(p.492). Mutations related to linkages in Mendelian disease together with successive emergence of variations in mapping of genes would be available. The aim of this piece of work is to examine potential applications of Next generation DNA sequencing technologies for human health and medicine. Focus will be made on cloning and library of genes of next gene sequencing 3(p.2-3).

Next generation sequencing can be applied in clinical molecular especially in the process of diagnosing cancer. Research shows that, for every 8 global deaths, one is as a consequence of cancer. This scenario is made dreary by the fact that cancer is a complex disease that is a derivative of various environmental, routine and genetic factors. Genetically, cancer has been associated with more that 350 human genes with the genetic factors expected to be on the rise. The germ like DNA comprises the cancer Genome upon which genetic modification is superimposed4 (p.198). Errors during cell division lead to passenger mutations that lead to neutral somatic mutations. Those genetic factors that contribute to progression of the growth of tumour...