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Lecture 20- Regenerative Medicine

* Growing cells and tissues that can be used to ____________________________________________ and organs

* Using stem cells

Tissue Regenerative Medicine

* The end goal:

* To create products ______________________________ or heal tissue defects.

* Replace diseased or damaged tissue

* Because……

* Donor tissues and organs are in __________________________

* We want to _________________________________ response by using our own cells or novel ways to protect transplant.

* Regenerate, repair and replace

* ________________________________

* Identify the cues that allow for regeneration without _______________________

* Like growing a new limb

* _____________________________

* Stimulate the tissue at a cell or molecular level, even at level of DNA, to repair itself.

* Replace

* A biological __________________________________ in the lab that can be implanted to replace the tissue or organ of interest

* Tissue-engineered products contain mixtures of the following:

* Biological components _________________________

* Can be genetically modified to behave a specific way

* Chemicals

* that tell the tissue to _____________________________

* A non-biological component

* ______________________________________

* Fibers, plastic, other natural components

* Gels

Scaffolds

* Various textures and materials

* Encourage ________________________________

* Allow nutrients to ___________________________

* Won’t___________________ the patient

* Transplants that match the patient

* Remove cells ________________________

* Grow in culture with or without biomaterials

* Give appropriate chemicals to make cells do ____________________________

* Replace into patient

A new bladder

* To make a bladder one need a scaffold and several ___________________________

Bone repair

* Obtain...