Assay of Aspirin

Week 32 - Hydrolysis of Aspirin

Week 33 - Assay of Aspirin Tablets

Week 34 - Stability of Aspirin

115 Report

Fairose Begum

Group G

Introduction

Aspirin (acetylsalicylic acid) is the salicylate ester of acetic acid. The compound occurs as a white, crystalline powder. It is a weak acid with a pKa of 3.5. Aspirin is slightly soluble in water and is freely soluble in alcohol. It is a member of a family of chemicals

called salicylates (acetylsalicylic acid) whose core structure is given below.

Chemicals in this family have been investigated for their medicinal properties for

centuries.

[pic]

The difference between salicylic acid (the ionized salt form of the acid is called

salicylate) and acetylsalicylic acid is the acetyl group (circled) that is on the

phenol (alcohol group attached directly to a benzene ring). Aspirin itself is not a

natural product, that is, it is not made by any organism (bacteria, plant, etc) in

nature. It can however, be made from salicylic acid, which is a natural product,

by functionalizing the phenol with an acetyl group.

Acetylsalicylic acid (Aspirin) consists of acidic and ester groups. It is known as a weak acid that has ability to take action as an anti-inflammatory drug. Aspirin also is used as an analgesic, antipyretic, and anti-platelet drug. The functional group ester can undergo hydrolysis where the ester bond breaks by water in acidic or basic conditions.

Mode of Action of Aspirin

Aspirin (acetylsalicylic acid) is a versatile drug that is consumed in huge quantities worldwide. It is a non-steroidal anti-inflammatory drug (NSAID) with a wide range of physiological effects. It works by inhibiting the activity of cyclo-oxygenase 1 and 2.

It also acts as an analgesic by decreasing the production of prostaglandins, which is linked to pain. It works by suppressing this hormone so that nociceptive nerve...