Ds5565 Industry 2015,Share and Size, Trends and Price, Forecast and Market Analysis to 2022

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DS5565 Industry 2015,Share and Size,Trends and

Price,Forecast and Market Analysis to 2022

Summary

Neuropathic pain (NP) is defined as a disorder of the sensorimotor system and is distinctly different

from nociceptive pain, which is a consequence of trauma, injury, or inflammation. The main difference

between neuropathic and nociceptive pain is the absence of a continuous nociceptive input in

neuropathic pain. Although the term neuropathic pain is used to describe a wide range of pain

syndromes with varying etiologies, this report focuses on 3 distinct forms of NP: Painful diabetic

neuropathy, Postherpetic neuralgia and trigeminal neuralgia. The main classes of drugs used to treat

these three neuropathic pain indications include anticonvulsants, antidepressants, opioids and topical

treatments. However, despite the availability of multiple pain medications only 50% of patients respond

to any given drug and there are numerous the side effects associated particularly with systemically

administered drugs, that reduce their tolerability. New treatments will target some key unmet needs in

terms of efficacy and tolerability, but opportunities will remain for drugs that can more reliably

eradicated NP in targeted patient populations, as well as offering an improved safety profile.

DS-5565 is an oral, small-molecule analgesic being developed by Daiichi Sankyo for the treatment of

PDN. It is a voltage-dependent calcium channel alpha-2-delta ligand, meaning that it has a mechanism of

action similar to Lyrica and gabapentin, and reduces pain through the inhibition of calcium channelassociated currents. These compounds bind to the a-2-d subunits (a-2-d-1 and a-2-d-2) of voltagedependent calcium channels, where the a-2-d-1 subunit is the main target for the analgesic effect of a-2-

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d ligands, while the a-2-d-2 subunit is thought to...