Cystic Fibrosis

Cystic Fibrosis OutLine By Tiffany Furleigh

* Cystic Fibrosis

Autosomal Recessive Inheritance

* By Tiffany Furleigh

* Symptoms

* Digestive

* Diarrhea

* Malnutrition

* Reproductive

* Infertility

* Pregnancy Complications

* Respiratory

* Chronic Coughing

* Bacterial Lung Infections

* Scarring of Lungs

* Severe Breathing Problems

* 1 in 3,500 Caucasians

* 1 in 17,000 African Americans

* 1 in 31,000 Asian Americans

* 10 million Americans are carriers of mutated CF gene

* Most common among the Caucasian population

* Diagnosed usually by 2 years of age

Treatment

* Antibiotics to prevent infections

* Chest Percussion Therapy

* Oxygen Therapy

* High protein diet

* Vitamin supplements

Prognosis

* Fatal Childhood Disease left untreated

* Average Life Span is 37 years

* Death by lung problems most common

* Cystic Fibrosis Punnett Square

* Pedigree Chart

* CFTR Gene Mutation

* CFTR gene instructs the transport of chloride ions needed in cells for mucus distribution around cells and organs.

* This regulates the flow of water in and out of cells for homeostasis and mucus placement.

* Lack of proper balance limits the cells mucus production. Too little chloride ions creates thick mucus build up.

* This mutation creates an imbalance in the cell’s membrane mucus that becomes thick and sticky which inhibits the normal function and clogs airways and ducts.

* References

* http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001167/#adam_000107.disease.causes

* http://www.nhlbi.nih.gov/health/health-topics/topics/cf/signs.html

* http://ghr.nlm.nih.gov/condition/cystic-fibrosis

* http://www.nlm.nih.gov/medlineplus/ency/article/000107.htm

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