Differental Behavioral State-Dependence in the Burst Properties of Ca3 and Ca1 Neurons

US008374696B2

(12) United States Patent

(10) Patent N0.:

(45) Date of Patent:

Sanchez et al.

(54)

Tropp Sneider, et al., “Differental Behavioral State-Dependence in

the Burst Properties of CA3 and CA1 Neurons”, 141 Neuroscience

(75) Inventors: Justin C. Sanchez, NeWberry, FL (US);

Paul R. Carney, Gainesville, FL (US)

1665-1677 (2006).

Chaovalitwongse, et al., “Performance of a seizure Warning algo

rithm based on the dynamics of intracranial EEG”, 64 Epilepsy

Research 93-113 (2005).

(73) Assignee: University of Florida Research

Sanchez, et al., “Evolving into epilepsy: Multiscale electrophysi

ological analysis and imaging in an animal model”, 198 Experimen

tal Neurology 31-47 (2006).

Carney, et al., “Quantitative Analysis of EEG in the Rat Limbic

Foundation, Inc., Gainesville, FL (U S)

Notice:

Subject to any disclaimer, the term of this

patent is extended or adjusted under 35

Epilepsy Model”, Neurology 62 Apr. 2004 (Suppl 5).

U.S.C. 154(b) by 690 days.

(Continued)

(21) App1.N0.: 11/520,222

(22) Filed:

Primary Examiner * Carl H Layno

Sep. 13, 2006

(65)

Assistant Examiner * Jeremiah Kimball

(74) Attorney, Agent, or Firm * Edwards Wildman Palmer

Prior Publication Data

US 2007/0067003 A1

LLP; Peter F. Corless; Brian R. Landry

Mar. 22, 2007

(57)

Related US. Application Data

ABSTRACT

The invention provides a micro-control neuroprosthetic

device and methods for predicting and controlling epileptic

(60) Provisional application No. 60/716,863, ?led on Sep.

14, 2005.

(51)

Feb. 12, 2013

Fried, et al., “Cerebral microdialysis combined With single-neuron

and electroencephalographic recording in neurosurgical patients”, J.

Neurosurg 91:697-705 (1999).

CLOSED-LOOP MICRO-CONTROL SYSTEM

FOR PREDICTING AND PREVENTING

EPILEPTIC SEIZURES

(*)

US 8,374,696 B2

neuronal activity. The device includes a detection system that

detects and collects electrophysiological...