Acute Myelogenous Leukemia

Adv Bio 4h genetic disease:

research paper on Actute Myelogenous Leukemia.

My subject is this interesting and rare type of leukemia, the acute myelogenous leukemia. I will treat about the process of this disease, the symptoms, the risk factors, the diagnosis, the treatments, and the prognosis.

The acute myelogenous leukemia (AML) is a fast-growing cancer which is located in the blood and the bone marrow. This disease has a fast development as suggest its name “acute”. It is a mutation of several genes in a type of myeloid stem cells. Normally a blood stem cell become a myeloid stem cell and be transformed in red blood cells, platelets and myeloblast and then white blood cells or it might become a lymphoid stem which will be developed into lymphoblast and then white blood cells. Instead, the cells which are supposed to become myeloblasts are abnormal and become leukemia which take place of the healthy cells which results in infection, easy bleeding or anemia and spread out in the central nervous system, the skin and the gums.

The AML has 8 subtypes, noted M0 to M7, according to the blood cells affected. Acute promyelocytic leukemia (APL) is a subtype of AML that happens when parts of two genes stick together. APL usually occurs in middle-aged adults. Symptoms of APL are bleeding and forming blood clots.

The AML is the most common type of acute leukemia with around 12000 new cases each year in the United States. Most of the patients are older than 65 years old because this is a genetic abnormality acquired during the life and usually are not hereditary even some susceptibility to the AML in a family can be possible. They are several other risk factors for the AML. More male are concerned than female. Smoking, using drugs, being exposed to radiation, chemical benzene and chemotherapy, having the Down`s syndrome, the Fanconi anemia, the Schwachman-Diamond syndrome, the Bloom's syndrome, and the ataxia telangiectasia”.

The symptoms of AML are caused by low...